Brandrup F, Larsen F S
Contact Dermatitis. 1979 May;5(3):148-50. doi: 10.1111/j.1600-0536.1979.tb04827.x.
A total of 79 nickel-sensitive patients (65 women, 14 men) were examined with regard to a present or past eczema corresponding to contact with metallic buttons in blue jeans; 63% of the women and 64% of the men had or had had eczema of this kind. Among 40% of the women below 30 years this was the primary site of manifestation. The seriousness of this sensitivity is illustrated by the fact that two-thirds of the nickel sensitive patients with button dermatitis had or had had eczema of the hands. The conclusion is that blue jean buttons should be made of a material which does not contain nickel, for instance zinc alloys which are presently used for some metallic buttons, or they should be designed in such a way that the button does not directly contact the skin.
共有79名对镍敏感的患者（65名女性，14名男性）接受了检查，以确定是否存在或曾经存在与蓝色牛仔裤金属纽扣接触相关的湿疹；63%的女性和64%的男性患有或曾经患有此类湿疹。在30岁以下的女性中，40%的人湿疹首发部位在此。这种敏感性的严重性体现在三分之二患有纽扣性皮炎的镍敏感患者患有或曾经患有手部湿疹这一事实上。结论是，蓝色牛仔裤纽扣应由不含镍的材料制成，例如目前用于一些金属纽扣的锌合金，或者其设计应使纽扣不直接接触皮肤。
