Kaufman S, Chalmer B, Heilman R, Beeken W
Dig Dis Sci. 1979 Apr;24(4):269-76. doi: 10.1007/BF01296539.
To better define the course of Crohn's disease, certain clinical, laboratory, and radiological features were studied prospectively in a representative group of 25 patients at intervals of up to 77 months. Eleven variables of potential use in assessing the course were analyzed for clinician preference, and the statistical relationship of one variable, the Crohn's disease activity index, to the other 10 was determined. Modest improvement was documented in three clinical variables, as well as in anemia, serum albumin, intestinal protein loss, and radiological extent of disease. Variables most frequently ranked high as reflections of the course of Crohn's disease were hematocrit and extent of disease, followed by body weight, stools per day, B12 absorption, serum albumin, and intestinal protein loss. The highest intervariable correlation was between improvement in protein loss and decrease in radiological extent (r = 0.75).
为了更好地明确克罗恩病的病程，对25例具有代表性的患者进行了前瞻性研究，观察某些临床、实验室及放射学特征，随访间隔长达77个月。分析了11个可能用于评估病程的变量，以了解临床医生的偏好，并确定其中一个变量即克罗恩病活动指数与其他10个变量之间的统计学关系。三个临床变量以及贫血、血清白蛋白、肠道蛋白丢失和疾病的放射学范围均有适度改善。最常被列为反映克罗恩病病程的高排名变量是血细胞比容和疾病范围，其次是体重、每日排便次数、维生素B12吸收、血清白蛋白和肠道蛋白丢失。蛋白丢失改善与放射学范围缩小之间的变量间相关性最高（r = 0.75）。
