Linder M C, Bryant R R, Lim S, Scott L E, Moor J E
Enzyme. 1979;24(2):85-95. doi: 10.1159/000458636.
In rats with transplantable mammary or hepatic tumors, plasma ceruloplasmin oxidase activity was increased 50--200%. This occurred progressively with tumors weighing 0.3% of body weight of more, and did not occur upon sham operation or implantation of normal tissue. Incorporation of [3H]-leucine indicated a specific enhancement of ceruloplasmin synthesis in the tumor-bearing rats, and a greater state of activation of the enzyme was also observed. The mechanism of the increase in ceruloplasmin levels in rats and humans with cancer thus appears to involve increased synthesis and activation of the enzyme.
在患有可移植性乳腺或肝脏肿瘤的大鼠中，血浆铜蓝蛋白氧化酶活性增加了50%至200%。当肿瘤重量达到体重的0.3%及以上时，这种情况会逐渐发生，而在假手术或植入正常组织时则不会出现。[3H] - 亮氨酸的掺入表明荷瘤大鼠中铜蓝蛋白合成有特异性增强，并且还观察到该酶的激活状态更高。因此，癌症大鼠和人类中铜蓝蛋白水平升高的机制似乎涉及该酶合成和激活的增加。
