米安色林增强大鼠肛门尾骨肌对乙酰胆碱的反应。

Mianserin potentiates responses to acetylcholine in the rat anococcygeus muscle.

作者信息

Doggrell S A

出版信息

Eur J Pharmacol. 1979 May 1;55(3):311-4. doi: 10.1016/0014-2999(79)90199-7.

Abstract

In the rat anococcygeus muscle, mianserin (1 and 10 muM) increased the magnitude of the maximal contractile responses to acetylcholine and carbamylcholine without affecting the maximal responses to (--)-noradrenaline. The potentiating effect of mianserin on responses to acetylcholine was maintained in the presence of 5muM phentolamine, following 6-hydroxy dopamine incubation of the tissues (1 mM for 3h) and in the presence of 1 muM nortriptyline. It is suggested that mianserin increases the sensitivity to acetylcholine by an action at the level of, or distal to, the cholinergic receptor.

摘要

在大鼠的肛门尾骨肌中，米安色林（1和10微摩尔）增加了对乙酰胆碱和氨甲酰胆碱的最大收缩反应幅度，而不影响对（-）-去甲肾上腺素的最大反应。在存在5微摩尔酚妥拉明的情况下、在组织经6-羟基多巴胺孵育（1毫摩尔，3小时）后以及在存在1微摩尔去甲替林的情况下，米安色林对乙酰胆碱反应的增强作用仍然存在。提示米安色林通过作用于胆碱能受体水平或其远端来增加对乙酰胆碱的敏感性。