抗抑郁药物对大鼠肛尾肌去甲肾上腺素蓄积及收缩反应的影响。
Effects of antidepressant drugs on noradrenaline accumulation and contractile responses in the rat anococcygeus muscle.
作者信息
Doggrell S A, Woodruff G N
出版信息
Br J Pharmacol. 1977 Mar;59(3):403-9. doi: 10.1111/j.1476-5381.1977.tb08393.x.
Abstract
1 The effect of a series of antidepressant drugs on noradrenaline accumulation was studied in the isolated anococcygeus muscle of the rat. 2 The most potent inhibitors of noradrenaline accumulation were nortriptyline, desipramine and protriptyline. Opipramol, trimipramine and iprindole were active only in high concentrations. 3 Contractions of the anococcygeus muscle produced by noradrenaline were strongly potentiated by nortriptyline, desipramine and protriptyline. Other uptake inhibitors were less active in potentiating the noradrenaline response. 4 Nortriptyline, in concentrations that potentiated the action of noradrenaline, reduced or abolished the response to tyramine.
摘要
在大鼠离体的尾骨肌中研究了一系列抗抑郁药对去甲肾上腺素蓄积的影响。
去甲肾上腺素蓄积的最强抑制剂是去甲替林、地昔帕明和普罗替林。奥匹哌醇、曲米帕明和茚满二胺仅在高浓度时才有活性。
去甲替林、地昔帕明和普罗替林强烈增强去甲肾上腺素引起的尾骨肌收缩。其他摄取抑制剂在增强去甲肾上腺素反应方面活性较低。
去甲替林在增强去甲肾上腺素作用的浓度下，降低或消除了对酪胺的反应。
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本文引用的文献
1
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2
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3
4
5
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Biochem Pharmacol. 1970 Dec;19(12):3021-8. doi: 10.1016/0006-2952(70)90088-2.
6
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9
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10
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Can J Physiol Pharmacol. 1974 Jun;52(3):430-40. doi: 10.1139/y74-058.
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