牛的委内瑞拉马脑炎病毒实验性感染
Experimental Venezuelan equine encephalomyelitis virus infection of the bovine.
作者信息
Walton T E, Johnson K M
出版信息
Infect Immun. 1972 Feb;5(2):155-9. doi: 10.1128/iai.5.2.155-159.1972.
Two groups of four dairy cows (Bos taurus) were infected subcutaneously with the epizootic Venezuelan equine encephalomyelitis virus (VEE) strains MF-8 and San Pelayo, respectively. Animals experienced no clinical illness, but all developed significant neutropenia. Virus was recovered once each from the blood of three animals but did not exceed 10(2.2) SMICLD(50) (Suckling mouse intracerebral lethal dose(50))/ml. Specific neutralizing antibodies appeared in the serum of all animals, but there were no significant differences in titers against different naturally occurring VEE subtypes. Dairy cattle thus appear to play no role in virus transmission during VEE epizootics but may serve as retrospective immunological sentinels of virus activity.
两组四只奶牛（Bos taurus）分别皮下感染了马脑脊髓炎委内瑞拉马脑炎病毒（VEE）的流行毒株MF - 8和圣佩莱约毒株。动物未出现临床疾病，但均出现了明显的中性粒细胞减少症。从三只动物的血液中各分离到一次病毒，但其滴度未超过10(2.2) SMICLD(50)（乳鼠脑内致死剂量(50)）/毫升。所有动物血清中均出现了特异性中和抗体，但针对不同自然发生的VEE亚型的抗体滴度没有显著差异。因此，奶牛在VEE流行期间似乎在病毒传播中不起作用，但可能作为病毒活动的回顾性免疫哨兵。
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