Montgomerie J Z, Kalmanson G M, Hubert E G, Guze L B
Infect Immun. 1972 Sep;6(3):330-4. doi: 10.1128/iai.6.3.330-334.1972.
Mice immunized subcutaneously with heat-killed Escherichia coli were protected from pyelonephritis produced by the intravenous route, but there was little or no protection from ascending infection. No significant protection from ascending or hematogenous pyelonephritis was demonstrated when immunization was accomplished by injecting heat-killed E. coli into the bladder. Heat-killed E. coli injected either subcutaneously or into the bladder protected mice from early endotoxic death after intravenous or bladder challenge.
皮下注射热灭活大肠杆菌免疫的小鼠可免受静脉途径所致肾盂肾炎的侵害，但对上行性感染几乎没有或没有保护作用。当通过将热灭活大肠杆菌注入膀胱来完成免疫时，未显示出对上行性或血源性肾盂肾炎有显著保护作用。皮下或膀胱注射热灭活大肠杆菌可保护小鼠免受静脉或膀胱攻击后早期内毒素性死亡。
