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Immunization against retrograde pyelonephritis. II. Prevention of retrograde Escherichia coli pyelonephritis with vaccines.逆行性肾盂肾炎的免疫接种。II. 用疫苗预防逆行性大肠杆菌肾盂肾炎。
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Experimental hematogenous pyelonephritis due to Escherichia coli in rabbits: the antibody response and its protective capacity.兔源大肠杆菌所致实验性血源性肾盂肾炎：抗体反应及其保护能力
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大鼠上行性大肠杆菌肾盂肾炎的预防及局部免疫的意义

Protection against ascending Escherichia coli pyelonephritis in rats and significance of local immunity.

作者信息

Kaijser B, Larsson P, Olling S

出版信息

Infect Immun. 1978 Apr;20(1):78-81. doi: 10.1128/iai.20.1.78-81.1978.

DOI:10.1128/iai.20.1.78-81.1978
PMID:352939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC421554/
Abstract

Acute pyelonephritis in rats caused by Escherichia coli O6K13H1 produced serum and urinary antibodies against O6 and K13 antigens. This was also seen after intravesical immunization with Formalin-killed bacteria. Both intraperitoneal and intravesical immunization with these Formalin-killed bacteria protected against ascending urinary tract infection induced by homologous bacteria. Passive transfer of urine containing both O6 and K13 antibodies also protected against infection. By absorption experiments it was shown that K13 antibodies were especially important.

摘要

由大肠杆菌O6K13H1引起的大鼠急性肾盂肾炎产生了针对O6和K13抗原的血清及尿液抗体。在用福尔马林灭活细菌进行膀胱内免疫后也观察到了这种情况。用这些福尔马林灭活细菌进行腹腔内和膀胱内免疫均可预防同源细菌引起的上行性尿路感染。含有O6和K13抗体的尿液的被动转移也可预防感染。通过吸收实验表明，K13抗体尤为重要。