逆行性肾盂肾炎的免疫接种。II. 用疫苗预防逆行性大肠杆菌肾盂肾炎。
Immunization against retrograde pyelonephritis. II. Prevention of retrograde Escherichia coli pyelonephritis with vaccines.
作者信息
Brooks S J, Lyons J M, Braude A I
出版信息
Am J Pathol. 1974 Feb;74(2):359-64.
Abstract
Vaccination with heat-killed or formalinized cells of E coli 0:111, or E coli 06 (Williams), prevented retrograde E coli pyelonephritis. Since there was no bacteremia and no urinary antibody, the vaccination appeared to protect by immune reactions operating in the kidney itself. The vaccine failed to protect against a highly virulent form of E coli 06 (Riffle), possibly because the amount of antibody to its lipopolysaccharide was inadequate. Since all three strains possessed K antigen in approximately equal amounts, the difference in results was not attributed to its presence.
摘要
用热灭活或甲醛化的大肠杆菌O:111或大肠杆菌O6（威廉姆斯菌株）进行疫苗接种，可预防逆行性大肠杆菌肾盂肾炎。由于不存在菌血症且尿液中无抗体，疫苗接种似乎是通过在肾脏自身发生的免疫反应起到保护作用。该疫苗未能预防高毒力的大肠杆菌O6（里夫尔菌株）感染，可能是因为针对其脂多糖的抗体量不足。由于所有三种菌株的K抗原含量大致相等，结果的差异并非归因于K抗原的存在。
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