用卡介苗免疫的兔子中的噬斑形成细胞。
Plaque-forming cells in rabbits immunized with BCG bacilli.
作者信息
Okuyama H, Morikawa K
出版信息
Infect Immun. 1972 Dec;6(6):893-8. doi: 10.1128/iai.6.6.893-898.1972.
Plaque-forming cells (PFC) in the regional lymph node, its efferent lymph, and the spleen of rabbits immunized with BCG were enumerated by localized hemolysis in gel, using sheep red blood cells coated with tuberculin protein. In the primary response, the maximal level of PFC production was reached at 5 days in the regional lymph node, and at 7 days in the spleen, whereas efferent lymphatic cells showed only a small number of PFC. Sharp peaks of PFC levels at 3 days were seen in the regional lymph node, spleen, and the efferent lymphatic cells in the secondary response. Blast cell outflow from the regional lymph node was maximal at 3 days in the secondary response as well as in the primary response. The relation between blast cell outflow and PFC production was discussed.
用涂有结核菌素蛋白的绵羊红细胞，通过凝胶中的局部溶血法对卡介苗免疫的兔的局部淋巴结、其输出淋巴管及脾脏中的空斑形成细胞（PFC）进行计数。在初次应答中，局部淋巴结在5天时达到PFC产生的最高水平，脾脏在7天时达到最高水平，而输出淋巴管细胞仅显示少量PFC。在二次应答中，局部淋巴结、脾脏及输出淋巴管细胞在3天时出现PFC水平的尖峰。在二次应答及初次应答中，局部淋巴结的母细胞流出在3天时均达到最大值。讨论了母细胞流出与PFC产生之间的关系。
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