Ellul-Micallef R
Br Med J (Clin Res Ed). 1983 Oct 1;287(6397):940-3. doi: 10.1136/bmj.287.6397.940.
The effects of terbutaline sulphate were studied in 30 patients who presented with chronic cough at an allergy clinic. After a three week baseline period terbutaline and its placebo were given for two periods of three weeks each in a randomised, double blind, crossover manner. Patients kept a daily record of day and night cough scores and peak expiratory flow readings. Twenty one patients responded to terbutaline; placebo produced no significant effect. Both day and night cough scores (p less than 0.001) and peak expiratory flow rates were significantly improved (p less than 0.05) by the end of the first week of treatment with terbutaline. This improvement was achieved with only a fairly small change in airway calibre.
在一家过敏诊所，对30例慢性咳嗽患者研究了硫酸特布他林的效果。经过为期3周的基线期后，以随机、双盲、交叉的方式，分别给予特布他林及其安慰剂，各为期3周。患者每天记录日夜咳嗽评分和呼气峰值流速读数。21例患者对特布他林有反应；安慰剂无显著效果。在使用特布他林治疗的第一周结束时，日夜咳嗽评分（p<0.001）和呼气峰值流速均显著改善（p<0.05）。这种改善仅通过气道口径的相当小的变化就得以实现。
