胰腺移植后的葡萄糖与胰岛素代谢
Glucose and insulin metabolism after pancreatic transplantation.
作者信息
Sells R A, Calne R Y, Hadjiyanakis V, Marshall V C
出版信息
Br Med J. 1972 Sep 16;3(5828):678-81. doi: 10.1136/bmj.3.5828.678.
Abstract
After removal of the pancreas pigs develop hyperglycaemia and ketosis. Both orthotopic and heterotopic transplants prevent hyperglycaemia but the animals so treated display markedly different patterns of glucose and insulin metabolism. Orthotopic graft recipients have normal glucose tolerance curves with raised plasma insulin levels. The glucose tolerance curves of heterotopic graft recipients show significant hypoglycaemia and very marked hyperinsulinaemia. These results are explicable by the diversion of the two pancreatic hormones from the liver, and possibly by the effect of ischaemia and denervation on the pancreas.
摘要
切除胰腺后，猪会出现高血糖和酮症。原位移植和异位移植均可预防高血糖，但接受此类治疗的动物表现出明显不同的葡萄糖和胰岛素代谢模式。原位移植受体的葡萄糖耐量曲线正常，但血浆胰岛素水平升高。异位移植受体的葡萄糖耐量曲线显示出明显的低血糖和非常显著的高胰岛素血症。这些结果可以通过两种胰腺激素从肝脏分流来解释，也可能是由于缺血和去神经对胰腺的影响。
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