胰腺移植后的葡萄糖与胰岛素代谢
Glucose and insulin metabolism after pancreatic transplantation.
作者信息
Sells R A, Calne R Y, Hadjiyanakis V, Marshall V C
出版信息
Br Med J. 1972 Sep 16;3(5828):678-81. doi: 10.1136/bmj.3.5828.678.
Abstract
After removal of the pancreas pigs develop hyperglycaemia and ketosis. Both orthotopic and heterotopic transplants prevent hyperglycaemia but the animals so treated display markedly different patterns of glucose and insulin metabolism. Orthotopic graft recipients have normal glucose tolerance curves with raised plasma insulin levels. The glucose tolerance curves of heterotopic graft recipients show significant hypoglycaemia and very marked hyperinsulinaemia. These results are explicable by the diversion of the two pancreatic hormones from the liver, and possibly by the effect of ischaemia and denervation on the pancreas.
摘要
切除胰腺后，猪会出现高血糖和酮症。原位移植和异位移植均可预防高血糖，但接受此类治疗的动物表现出明显不同的葡萄糖和胰岛素代谢模式。原位移植受体的葡萄糖耐量曲线正常，但血浆胰岛素水平升高。异位移植受体的葡萄糖耐量曲线显示出明显的低血糖和非常显著的高胰岛素血症。这些结果可以通过两种胰腺激素从肝脏分流来解释，也可能是由于缺血和去神经对胰腺的影响。
相似文献
1
Glucose and insulin metabolism after pancreatic transplantation.
Br Med J. 1972 Sep 16;3(5828):678-81. doi: 10.1136/bmj.3.5828.678.
2
The effect of experimental heterotopic pancreatic allotransplantation on the insulin response to oral glucose administration.
Scand J Gastroenterol Suppl. 1976;37:47-51.
3
Beta-cell response and insulin sensitivity after segmental pancreatic autotransplantation with systemic venous drainage.
Life Support Syst. 1985;3 Suppl 1:701-6.
4
The enteral insulin-stimulation after pancreas transplantation in the pig.
Diabetologia. 1976 Dec;12(6):617-20. doi: 10.1007/BF01220640.
5
Endocrine function of the pancreatic allograft.
Endocrinology. 1968 Apr;82(4):731-41. doi: 10.1210/endo-82-4-731.
6
Effect of venous drainage to the vena cava and denervation on endocrine function of pancreatic segments in dogs.
Transplant Proc. 1984 Jun;16(3):769-72.
7
Function of the duct-ligated canine pancreatic allograft.
Eur Surg Res. 1975;7(4-5):212-29. doi: 10.1159/000127807.
8
9
The effect of pancreatic polypeptide on glucose disposal after surgical alterations of the pancreas.
Ann Surg. 1992 Nov;216(5):574-82. doi: 10.1097/00000658-199211000-00009.
10
Evaluation of insulin secretion after pancreas autotransplantation by oral or intravenous glucose challenge.
Ann Surg. 1986 Nov;204(5):585-93. doi: 10.1097/00000658-198611000-00013.
引用本文的文献
1
Pancreatic hypofunction in extrahepatic portal venous obstruction.
Gut. 1980 Mar;21(3):227-31. doi: 10.1136/gut.21.3.227.
2
Glucose and insulin changes following a renoportal shunt in streptozotocin diabetic rats with pancreatic islet isografts under the kidney capsule.
Diabetologia. 1982 Oct;23(4):343-6. doi: 10.1007/BF00253742.
3
The long-term allografted rat islet. A histologic and immunohistologic study.
Am J Pathol. 1983 May;111(2):166-73.
4
Long term studies of pancreas transplantation in experimental diabetes mellitus.
Ann Surg. 1975 Sep;182(3):198-206. doi: 10.1097/00000658-197509000-00003.
5
Proceedings: Clinical pancreatic allotransplantation: a review of world results.
Ann R Coll Surg Engl. 1976 Jul;58(4):326.
6
Extended survival of pancreatic islet allografts in the testis of guinea-pigs.
J Anat. 1977 Sep;124(Pt 1):1-8.
7
Current state of transplantation of the pancreas.
Ann R Coll Surg Engl. 1978 Jan;60(1):21-7.
本文引用的文献
1
Studies on tissue uptake of insulin in man using a differential immunoassay for endogenous and exogenous insulin.
J Clin Invest. 1961 Nov;40(11):2092-102. doi: 10.1172/JCI104435.
2
Further immunological studies on the form of circulating insulin.
J Endocrinol. 1962 Jun;24:263-77. doi: 10.1677/joe.0.0240263.
3
TOTAL PANCREATIC ALLOGRAFTS IN PANCREATECTOMIZED DOGS.
Arch Surg. 1965 Apr;90:521-6. doi: 10.1001/archsurg.1965.01320100065011.
4
Microcirculation in the islets of Langerhans of the mouse.
Anat Rec. 1963 Jun;146:117-23. doi: 10.1002/ar.1091460205.
5
Studies on the state of insulin in blood. The regulation of "free" insulin and insulin complexes in the blood of diabetic and non-diabetic subjects.
N Engl J Med. 1962 Nov 8;267:953-7. doi: 10.1056/NEJM196211082671902.
6
Immunoassay of insulin with insulin antibody preciptate.
Lancet. 1963 Jan 26;1(7274):200. doi: 10.1016/s0140-6736(63)91215-7.
7
Pancreatic function after normothermic ischemia. I. In vivo ischemia.
Am J Surg. 1970 Dec;120(6):687-92. doi: 10.1016/s0002-9610(70)80036-8.
8
Orthotopic allotransplantation of the pancreas.
Am J Surg. 1967 Jan;113(1):70-6. doi: 10.1016/0002-9610(67)90259-0.
9
Pancreatic function after normothermic ischemia. II. Cadaveric transplantation.
Am J Surg. 1970 Dec;120(6):693-6. doi: 10.1016/s0002-9610(70)80037-x.
10
Pancreatico-duodenal allotransplantation: experimental and clinical experience.
Ann Surg. 1970 Sep;172(3):405-36. doi: 10.1097/00000658-197009000-00010.
Zotero 插件