淋巴细胞激活的生物学表现。II. 胸腺来源抑制性淋巴细胞群体的产生。
Biological expressions of lymphocyte activation. II. Generation of a population of thymus-derived suppressor lymphocytes.
作者信息
Rich R R, Pierce C W
出版信息
J Exp Med. 1973 Mar 1;137(3):649-59. doi: 10.1084/jem.137.3.649.
A population of thymus-derived lymphocytes has been identified that, upon activation by the nonspecific plant mitogen concanavalin A, suppresses the development of plaque-forming cell responses in fresh or 48-h antigen-stimulated cultures of mouse spleen cells. Suppressor cells can inhibit both primary and secondary IgM and IgG responses in vitro. X-irradiation before activation of peripheral thymus-derived cells by concanavalin A abrogates generation of suppressor cells. After a 48 h activation period, however, the function of concanavalin A-activated suppressor cells is radioresistant. As yet uncertain is whether these suppressor cells are a population of cells distinct from thymus-derived "helper" cells. In certain important regards, the cells mediating these two opposing functions share similar characteristics; the effect observed may be determined by the circumstances of activation or the numbers of activated cells, and may consequently represent different functions of a single thymus-derived regulator cell population.
已鉴定出一群胸腺来源的淋巴细胞，在被非特异性植物有丝分裂原刀豆球蛋白A激活后，可抑制新鲜或经48小时抗原刺激的小鼠脾细胞培养物中噬斑形成细胞反应的发展。抑制细胞在体外可抑制初次和二次IgM及IgG反应。在用刀豆球蛋白A激活外周胸腺来源细胞之前进行X射线照射可消除抑制细胞的产生。然而，在48小时的激活期后，刀豆球蛋白A激活的抑制细胞的功能具有放射抗性。这些抑制细胞是否是与胸腺来源的“辅助”细胞不同的细胞群体尚不确定。在某些重要方面，介导这两种相反功能的细胞具有相似的特征；观察到的效应可能由激活的环境或激活细胞的数量决定，因此可能代表单个胸腺来源调节细胞群体的不同功能。
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