影响酵母中rho因子维持的核外突变的证据。
Evidence for an extrakaryotic mutation affecting the maintenance of the rho factor in yeast.
作者信息
Handwerker A, Schweyen R J, Wolf K, Kaudewitz F
出版信息
J Bacteriol. 1973 Mar;113(3):1307-10. doi: 10.1128/jb.113.3.1307-1310.1973.
Abstract
A newly isolated, temperature-sensitive mutant of a haploid strain of Saccharomyces cerevisiae is described. Its shift to nonpermissive temperature (35 C) resulted in an irreversible change to rho(-), causing, within four to six generations, more than 90% of the cells to form petite colonies. Genetic analysis revealed extrakaryotic inheritance of this temperature-sensitive mutation. Data presented indicate mutation of a gene in the mitochondrial deoxyribonucleic acid affecting the maintenance of the rho factor.
摘要
本文描述了一种新分离出的酿酒酵母单倍体菌株的温度敏感突变体。将其转移至非允许温度（35℃）会导致不可逆地转变为ρ（-）型，在四到六代内，超过90%的细胞形成小菌落。遗传分析显示该温度敏感突变具有核外遗传特性。所呈现的数据表明线粒体脱氧核糖核酸中的一个基因发生突变，影响了ρ因子的维持。
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