Pour P, Salmasizadeh S
Cancer Lett. 1978 Jul;5(1):13-8. doi: 10.1016/s0304-3835(78)80004-4.
Subcutaneous injection of N-nitrosobis(2-oxypropyl)amine (BOP) induced thyroid follicular adenomas and carcinomas in MRC rats. The tumor yield was 50% following a single dose and 60% after weekly treatment for life. In males the tumor incidence was slightly higher and the latency period shorter, while in females, the tumors were larger. Sites of origin, size, multiplicity and morphologic patterns of tumors were analyzed in relation to dose and sex. The possible mechanisms involved in tumorigenesis are discussed.
皮下注射N-亚硝基双（2-氧代丙基）胺（BOP）可在MRC大鼠中诱发甲状腺滤泡腺瘤和癌。单次给药后肿瘤发生率为50%，终身每周治疗后为60%。雄性大鼠的肿瘤发生率略高，潜伏期较短，而雌性大鼠的肿瘤则较大。分析了肿瘤的起源部位、大小、多发性和形态学模式与剂量和性别的关系。讨论了肿瘤发生的可能机制。
