用胞壁酰二肽及其某些类似物治疗对小鼠抗单核细胞增生李斯特菌能力的影响。
Effects of treatment with muramyl dipeptide and certain of its analogs on resistance to Listeria monocytogenes in mice.
作者信息
Humphres R C, Henika P R, Ferraresi R W, Krahenbuhl J L
出版信息
Infect Immun. 1980 Nov;30(2):462-6. doi: 10.1128/iai.30.2.462-466.1980.
Abstract
Studies were carried out to determine whether treatment of mice with the synthetic adjuvant muramyl dipeptide (MDP) afforded any resistance to infection with Listeria monocytogenes. Regardless of the timing, dose, or route of administration, there was no evidence that treatment with either MDP or two of its analogs (des-MDP or MDP-D-D) induced any resistance to listeria infection in BALB/c, CBA/J, or C57BL/6J mice. In contrast, pretreatment with MDP induced marked protection to infection with Streptococcus pneumoniae (type III).
摘要
开展了多项研究以确定用合成佐剂胞壁酰二肽（MDP）处理小鼠是否能使其对单核细胞增生李斯特菌感染产生任何抗性。无论给药时间、剂量或途径如何，均没有证据表明用MDP或其两种类似物（去甲MDP或MDP-D-D）处理能使BALB/c、CBA/J或C57BL/6J小鼠对李斯特菌感染产生任何抗性。相比之下，用MDP进行预处理可显著保护小鼠免受肺炎链球菌（III型）感染。
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