左旋多巴与甲基多巴之间的相互作用。
Interaction between levodopa and methyldopa.
作者信息
Gibberd F B, Small E
出版信息
Br Med J. 1973 Apr 14;2(5858):90-1. doi: 10.1136/bmj.2.5858.90.
Abstract
The interaction between methyldopa and levodopa was studied in 18 patients with Parkinsonism. Together they produced a fall in blood pressure in doses which when given alone had no effect or only a slight hypotensive effect. Severe hypotension never occurred. It is reasonable to give methyldopa to hypertensive patients on levodopa but the regimen should be initiated in hospital.
摘要
对18例帕金森病患者研究了甲基多巴与左旋多巴之间的相互作用。二者合用时，给予单独使用时无作用或仅有轻微降压作用的剂量，可使血压下降。严重低血压从未发生过。对正在服用左旋多巴的高血压患者给予甲基多巴是合理的，但该治疗方案应在医院开始实施。
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本文引用的文献
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PARKINSONISM ASSOCIATED WITH ALPHA-METHYLDOPA THERAPY.与α-甲基多巴治疗相关的帕金森综合征
Br Med J. 1964 Jul 18;2(5402):168. doi: 10.1136/bmj.2.5402.168.
2
Parkinsonism occurring with methyldopa treatment.甲基多巴治疗引发的帕金森综合征。
Br Med J. 1963 Apr 13;1(5336):1001. doi: 10.1136/bmj.1.5336.1001.
3
Renin-aldosterone system in Parkinson's disease.帕金森病中的肾素-醛固酮系统。
Science. 1969 Jul 18;165(3890):291-2. doi: 10.1126/science.165.3890.291.
4
Levodopa, Parkinson's disease, and hypotension.
Ann Intern Med. 1970 May;72(5):751-2. doi: 10.7326/0003-4819-72-5-751.
5
Autoimmunity in patients treated with levodopa.接受左旋多巴治疗患者的自身免疫
JAMA. 1969 Feb 17;207(7):1353-4.
6
Use of levodopa with other drugs.左旋多巴与其他药物联合使用。
Lancet. 1970 Dec 19;2(7686):1283-5. doi: 10.1016/s0140-6736(70)92244-0.
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