Whiting P H, Petersen J, Simpson J G
Br J Exp Pathol. 1981 Apr;62(2):200-6.
Gentamicin, at doses of 50 or 100 mg/kg body wt administered daily to healthy male MF1 mice by i.p. injection for either 7 or 10 days caused proximal tubular cell damage shown both by the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and by electron microscopy. The tubular damage was maximal at 7 days. Concomitant administration of any of 3 diuretics-frusemide, bumetanide or piretanide at 5,0.5 and 1 mg/kg body wt/day respectively-resulted in less tubular damage than that caused by gentamicin alone. This finding of protection by diuretics contrasts with those of previous studies of combination gentamicin-diuretic therapy.
将庆大霉素以50或100毫克/千克体重的剂量，通过腹腔注射每日给予健康雄性MF1小鼠，持续7天或10天，会导致近端肾小管细胞损伤，这通过N - 乙酰 - β - D - 氨基葡萄糖苷酶（NAG）的尿排泄以及电子显微镜检查得以显示。肾小管损伤在第7天时最为严重。分别以5、0.5和1毫克/千克体重/天的剂量同时给予三种利尿剂（速尿、布美他尼或吡咯他尼）中的任何一种，所导致的肾小管损伤比单独使用庆大霉素时要少。利尿剂的这种保护作用的发现与先前关于庆大霉素 - 利尿剂联合治疗的研究结果形成了对比。
