萘啶酸和氨苄西林治疗重症志贺菌病的疗效比较
Comparative efficacy of nalidixic acid and ampicillin for severe shigellosis.
作者信息
Haltalin K C, Nelson J D, Kusmiesz H T
出版信息
Arch Dis Child. 1973 Apr;48(4):305-12. doi: 10.1136/adc.48.4.305.
Abstract
Nalidixic acid is effective against shigellae including strains multiply-resistant to antibiotics. A comparative study of acute shigellosis in infants and children involved 19 patients treated with ampicillin and 17 treated with nalidixic acid. Stool cultures remained positive longer with nalidixic acid treatment than with ampicillin therapy, and clinical response was slower. The rate of response to therapy was correlated with the serum levels of ampicillin. Though nalidixic acid eliminates shigellae from stools more rapidly than with symptomatic therapy alone, it cannot be recommended for routine treatment of acute shigellosis since it has little effect on the natural course of the illness. In special circumstances when dealing with shigellae that are resistant to ampicillin, tetracycline, and chloramphenicol, nalidixic acid may have a limited use.
摘要
萘啶酸对包括多重耐药菌株在内的志贺氏菌有效。一项针对婴幼儿急性志贺氏菌病的对比研究涉及19例接受氨苄西林治疗的患者和17例接受萘啶酸治疗的患者。与氨苄西林治疗相比，萘啶酸治疗后粪便培养阳性持续时间更长，临床反应也更慢。治疗反应率与氨苄西林的血清水平相关。虽然萘啶酸比单纯对症治疗能更快地清除粪便中的志贺氏菌，但由于它对疾病的自然病程影响不大，因此不推荐用于急性志贺氏菌病的常规治疗。在处理对氨苄西林、四环素和氯霉素耐药的志贺氏菌的特殊情况下，萘啶酸可能有有限的用途。
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