引起旅行者腹泻的志贺菌分离株的抗菌药物耐药性。
Antimicrobial resistance of Shigella isolates causing traveler's diarrhea.
作者信息
Vila J, Gascon J, Abdalla S, Gomez J, Marco F, Moreno A, Corachan M, Jimenez de Anta T
机构信息
Department of Microbiology, University of Barcelona, School of Medicine, Spain.
出版信息
Antimicrob Agents Chemother. 1994 Nov;38(11):2668-70. doi: 10.1128/AAC.38.11.2668.
Abstract
Shigella isolates were identified as a cause of traveler's diarrhea in 67 (10%) of 675 patients and were tested for resistance to seven antimicrobial agents in a comparative study with those causing nontraveler's diarrhea in Spain. Ampicillin and chloramphenicol resistance was more frequent in Shigella flexneri (60 and 46%, respectively) than in Shigella sonnei (32 and 18%, respectively) and in travel-related isolates (P < 0.05 and 0.04, respectively). Of S. sonnei isolates from patients with traveler's diarrhea, 73 and 54% showed tetracycline and trimethoprim-sulfamethoxazole resistance, respectively, compared with only 8% of isolates from patients without a history of travel to developing countries (P < 0.007 and P < 0.0002). Low-level resistance to cephalosporins was found, whereas quinolone-resistant strains were not detected among travel-related Shigella isolates. Thus, quinolones may be an effective alternative therapy for travel-related shigellosis.
摘要
在675名患者中，67例（10%）的志贺菌分离株被确定为旅行者腹泻的病因，并在一项与西班牙非旅行者腹泻病因的比较研究中对其进行了七种抗菌药物的耐药性检测。弗氏志贺菌对氨苄西林和氯霉素的耐药性（分别为60%和46%）比宋内志贺菌（分别为32%和18%）以及与旅行相关的分离株更为常见（P值分别<0.05和0.04）。在旅行者腹泻患者的宋内志贺菌分离株中，分别有73%和54%对四环素和甲氧苄啶-磺胺甲恶唑耐药，而在无前往发展中国家旅行史患者的分离株中这一比例仅为8%（P值<0.007和P值<0.0002）。发现对头孢菌素存在低水平耐药，而在与旅行相关的志贺菌分离株中未检测到喹诺酮耐药菌株。因此，喹诺酮类药物可能是治疗与旅行相关的志贺菌病的有效替代疗法。
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