大肠杆菌K-12中的D-丝氨酸转运系统。
D-serine transport system in Escherichia coli K-12.
作者信息
Cosloy S D
出版信息
J Bacteriol. 1973 May;114(2):679-84. doi: 10.1128/jb.114.2.679-684.1973.
Abstract
The d-serine transport system in Escherichia coli K-12 was studied by use of a mutant unable to form d-serine deaminase, yet resistant to d-serine. The mutant is greatly impaired in its ability to accumulate d-serine, d-alanine, and glycine. Transport of l-alanine is partially affected but transport of l-serine is unaffected. The mutant is also resistant to d-cycloserine, indicating that d-serine is transported by the system responsible for uptake of d-cycloserine. The d-serine transport system is not inducible, but appears to be formed constitutively, as are the transport systems of most amino acids. The transport mutation appears to be multistep and maps to the right of malB on the E. coli linkage map.
摘要
利用一株无法形成d-丝氨酸脱氨酶但对d-丝氨酸具有抗性的突变体，对大肠杆菌K-12中的d-丝氨酸转运系统进行了研究。该突变体在积累d-丝氨酸、d-丙氨酸和甘氨酸的能力方面受到极大损害。l-丙氨酸的转运受到部分影响，但l-丝氨酸的转运未受影响。该突变体对d-环丝氨酸也具有抗性，这表明d-丝氨酸是由负责d-环丝氨酸摄取的系统转运的。d-丝氨酸转运系统不是诱导型的，而是似乎像大多数氨基酸的转运系统一样组成性形成的。转运突变似乎是多步骤的，并且在大肠杆菌连锁图谱上定位在malB的右侧。
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