免疫反应的调节。VII. F(ab')2 或完整 IgG 抗体的体外免疫抑制作用。
Regulation of the immune response. VII. In vitro immunosuppression by F(ab') 2 or intact IgG antibodies.
作者信息
Lees R K, Sinclair N R
出版信息
Immunology. 1973 Apr;24(4):735-50.
Abstract
F(ab') antibody is 5–100 times less efficient than intact IgG antibody in inhibiting an immune response to sheep erythrocytes. This observation constitutes further proof that the Fc portion of antibody possesses an immunoregulatory function which is not dependent on its role in renal tubular reabsorption.
摘要
F(ab')抗体在抑制对绵羊红细胞的免疫反应方面，其效率比完整的IgG抗体低5至100倍。这一观察结果进一步证明，抗体的Fc部分具有免疫调节功能，该功能不依赖于其在肾小管重吸收中的作用。
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The specific suppression of the early immune response in mice by "slow" and "fast" migrating 7S mouse antibody fractions.“慢速”和“快速”迁移的7S小鼠抗体组分对小鼠早期免疫反应的特异性抑制
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