备解素在过敏性紫癜和特发性局灶性肾炎中的肾小球沉积。
Glomerular deposition of properdin in Henoch-Schönlein syndrome and idiopathic focal nephritis.
作者信息
Evans D J, Williams D G, Peters D K, Sissons J G, Boulton-Jones J M, Ogg C S, Cameron J S, Hoffbrand B I
出版信息
Br Med J. 1973 Aug 11;3(5875):326-8. doi: 10.1136/bmj.3.5875.326.
Abstract
Biopsy of renal tissue from four patients with idiopathic focal nephritis and three patients with Henoch-Schönlein syndrome showed that C3 and properdin were deposited with IgA in the glomerular mesangium, C1q could not be detected. These observations suggest that glomerular injury in disorders characterized by mesangial deposits of IgA and C3 is mediated via the properdin system.
摘要
对4例特发性局灶性肾炎患者和3例过敏性紫癜性肾炎患者的肾组织活检显示，C3和备解素与IgA一起沉积于肾小球系膜，未检测到C1q。这些观察结果提示，以IgA和C3系膜沉积为特征的疾病中的肾小球损伤是通过备解素系统介导的。
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