大肠杆菌K-12中酪氨酸和苯丙氨酸的生物合成：不同tyrR等位基因之间的互补作用
Tyrosine and phenylalanine biosynthesis in Escherichia coli K-12: complementation between different tyrR alleles.
作者信息
Im S W, Pittard J
出版信息
J Bacteriol. 1973 Sep;115(3):1145-50. doi: 10.1128/jb.115.3.1145-1150.1973.
Abstract
Dominance tests in diploids have confirmed that the product of the tyrR gene is involved in a negative control system affecting the synthesis of both 3-deoxy-d-arabinoheptulosonic acid 7-phosphate (DAHP) synthetase (tyr) and DAHP synthetase (phe). Some tyrR mutants are derepressed for the synthesis of both DAHP synthetase (tyr) and (phe), whereas others are derepressed for the synthesis of DAHP synthetase (tyr) but overrepressed for the synthesis of DAHP synthetase (phe). Complementation tests between these alleles confirm that they are in the same cistron. The allele causing overrepression of enzyme synthesis is dominant over both the wild type and the derepressing allele in diploids.
摘要
二倍体中的显性测试已证实，tyrR基因的产物参与了一个负控制系统，该系统影响3-脱氧-D-阿拉伯庚酮糖酸7-磷酸（DAHP）合成酶（tyr）和DAHP合成酶（phe）的合成。一些tyrR突变体在DAHP合成酶（tyr）和（phe）的合成上是去阻遏的，而另一些在DAHP合成酶（tyr）的合成上是去阻遏的，但在DAHP合成酶（phe）的合成上是超阻遏的。这些等位基因之间的互补测试证实它们位于同一个顺反子中。导致酶合成超阻遏的等位基因在二倍体中对野生型和去阻遏等位基因都是显性的。
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