大肠杆菌K-12中3-脱氧-D-阿拉伯庚酮糖-7-磷酸合成酶活性与芳香族维生素合成的关系调控
Regulation of 3-deoxy-D-arabino-heptulosonic 7-phosphate acid synthetase activity in relation to the synthesis of the aromatic vitamins in Escherichia coli K-12.
作者信息
Wallace B J, Pittard J
出版信息
J Bacteriol. 1969 Sep;99(3):707-12. doi: 10.1128/jb.99.3.707-712.1969.
Abstract
Both in vivo and in vitro experiments on wild-type Escherichia coli K-12 and mutant strains possessing only single 3-deoxy-d-arabino-heptulosonic 7-phosphate acid (DAHP) synthetase isoenzymes indicated that, under conditions when all three isoenzymes are fully repressed, sufficient chorismate is still formed for the synthesis of aromatic vitamins. Under repressed conditions both DAHP synthetase (phe) and (trp), but not DAHP synthetase (tyr), were shown to contribute to vitamin production.
摘要
对野生型大肠杆菌K-12以及仅拥有单一3-脱氧-D-阿拉伯庚酮糖-7-磷酸（DAHP）合成酶同工酶的突变菌株进行的体内和体外实验均表明，在所有三种同工酶均被完全抑制的条件下，仍会形成足够的分支酸用于合成芳香族维生素。在抑制条件下，DAHP合成酶（苯丙氨酸）和（色氨酸），而非DAHP合成酶（酪氨酸），被证明有助于维生素的产生。
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本文引用的文献
1
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J Biol Chem. 1951 Nov;193(1):265-75.
2
[The biosynthesis of beta-galactosidase (lactase) in Escherichia coli; the specificity of induction].[大肠杆菌中β-半乳糖苷酶（乳糖酶）的生物合成；诱导的特异性]
Biochim Biophys Acta. 1951 Nov;7(4):585-99. doi: 10.1016/0006-3002(51)90072-8.
3
END-PRODUCT REGULATION OF THE GENERAL AROMATIC-PATHWAY IN ESCHERICHIA COLI W.大肠杆菌W中一般芳香族途径的终产物调节
Biochim Biophys Acta. 1963 Sep 3;77:170-2. doi: 10.1016/0006-3002(63)90489-x.
4
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J Biol Chem. 1962 Nov;237:3566-70.
5
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J Bacteriol. 1967 Jun;93(6):1938-42. doi: 10.1128/jb.93.6.1938-1942.1967.
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J Bacteriol. 1967 Jan;93(1):502-3. doi: 10.1128/jb.93.1.502-503.1967.
7
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J Bacteriol. 1967 Jan;93(1):237-44. doi: 10.1128/jb.93.1.237-244.1967.
8
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J Bacteriol. 1966 Apr;91(4):1494-508. doi: 10.1128/jb.91.4.1494-1508.1966.
9
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Biochim Biophys Acta. 1965 Jul 8;104(2):377-89. doi: 10.1016/0304-4165(65)90343-0.
10
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