Kristensen J K, Henriksen O
J Invest Dermatol. 1978 Mar;70(3):156-8. doi: 10.1111/1523-1747.ep12258579.
Passive distensibility of resistance vessels in subcutaneous tissue of hand and leg was examined in 6 normals and 8 patients suffering from generalized scleroderma of the acrosclerosis type. Local paralysis of smooth muscle was obtained by injection of papaverine and increase in transmural pressure by lowering the limb. Blood flow was estimated by the local 133Xenon wash-out method. Distensibility of blood vessels in subcutaneous tissue in generalized scleroderma was not decreased to a significant degree, whereas, both in patients and normals, the blood vessels of the leg exhibited diminished distensibility compared to blood vessels of the hand. The findings suggest that the morphologic changes of vascular and extravascular tissue observed in sclerodermic skin do not affect distensibility of the vascular bed in subcutaneous tissue.
对6名正常人及8名患肢端硬化型全身性硬皮病的患者，检查了手部和腿部皮下组织中阻力血管的被动扩张性。通过注射罂粟碱使平滑肌局部麻痹，并通过降低肢体高度来增加跨壁压力。采用局部133氙洗脱法估计血流量。全身性硬皮病患者皮下组织血管的扩张性并未显著降低，然而，无论是患者还是正常人，腿部血管的扩张性与手部血管相比均有所降低。这些发现表明，在硬皮病皮肤中观察到的血管及血管外组织的形态学改变，并不影响皮下组织血管床的扩张性。
