Angles-Cano E, Sultan Y, Clauvel J P
J Lab Clin Med. 1979 Aug;94(2):312-23.
We studied 28 patients with SLE, five of whom had had thrombotic episodes. Platelet function and coagulation and fibrinolytic studies were performed to determine whether any of these factors may predispose to thrombosis in SLE. An inhibitor of blood coagulation was detected in 12 patients, and von Willebrand's syndrome was observed in two others. The most striking findings which could be correlated with thromboembolic phenomena were the increase in VII R:WF and the absence of plasminogen activator release after venous occlusion. Both proteins are synthesized by the endothelial cell, and the abnormalities observed are possibly related to damage of the vascular endothelium by immune complexes observed in SLE.
我们研究了28例系统性红斑狼疮（SLE）患者，其中5例曾有血栓形成发作。进行了血小板功能、凝血及纤溶研究，以确定这些因素中是否有任何因素可能使SLE患者易发生血栓形成。在12例患者中检测到一种凝血抑制剂，另外2例观察到血管性血友病综合征。与血栓栓塞现象相关的最显著发现是VII R:WF增加以及静脉闭塞后纤溶酶原激活物释放缺乏。这两种蛋白均由内皮细胞合成，观察到的异常可能与SLE中所见免疫复合物对血管内皮的损伤有关。
