Volkman A, Collins F M
Infect Immun. 1973 Nov;8(5):814-8. doi: 10.1128/iai.8.5.814-818.1973.
Rats infected intravenously with Salmonella enteritidis develop a chronic destructive polyarthritis. The joint lesions resemble those of human rheumatoid arthritis in distribution and pathology. On the basis of histological and microbiological studies, involvement does not appear to be the result of intra-articular sepsis. Instead, the data favor the view that transient infection incites an immunological response that localizes in the joint and becomes destructive.
静脉注射肠炎沙门氏菌感染的大鼠会患上一种慢性破坏性多关节炎。关节病变在分布和病理学上与人类类风湿性关节炎相似。基于组织学和微生物学研究,关节受累似乎并非关节内脓毒症所致。相反,数据支持这样一种观点,即短暂感染引发免疫反应,该反应定位于关节并具有破坏性。