Zentner G M, Cardinal J R, Gregonis D E
J Pharm Sci. 1979 Jun;68(6):794-5. doi: 10.1002/jps.2600680635.
Hydrogels prepared from poly(hydroxyethyl methacrylate) are biocompatible and highly permeable to low molecular weight solutes. Permeation rates can be varied by altering the cross-linker concentration or using copolymers; the latter are chosen to alter the hydrogel equilibrium hydration. These factors suggest that hydrogels are good candidates for controlled-release drug delivery devices. Hydrogels may be synthesized using various temperatures, initiators (nature and concentration), and solvents (nature and concentration). This study demonstrated that progesterone permeation through poly(hydroxyethyl methacrylate) films is independent of polymerization solvent (nature and concentration) for the solvents, water, ethanol, and tert-butyl alcohol. The importance of hydrogel equilibrium hydration in progesterone permeation is emphasized.
由聚甲基丙烯酸羟乙酯制备的水凝胶具有生物相容性，且对低分子量溶质具有高渗透性。通过改变交联剂浓度或使用共聚物可以改变渗透速率；选择后者是为了改变水凝胶的平衡水合作用。这些因素表明水凝胶是控释给药装置的良好候选材料。可以使用各种温度、引发剂（性质和浓度）以及溶剂（性质和浓度）来合成水凝胶。本研究表明，对于水、乙醇和叔丁醇等溶剂，孕酮透过聚甲基丙烯酸羟乙酯薄膜的渗透与聚合溶剂（性质和浓度）无关。强调了水凝胶平衡水合作用在孕酮渗透中的重要性。
