Drobník J, Spacek P, Wichterle O
J Biomed Mater Res. 1974 Jan;8(1):45-51. doi: 10.1002/jbm.820080106.
Permeation parameters of four anti-tumor drugs across membranes prepared from hydrophilic methacrylate gels were measured and compared with the permeation of NaCl. It was found that by increasing the ratio of butyl methacrylate (BMA) to hydroxyethyl methacrylate (HEMA), the rate of diffusion can be lowered to practically zero at 20% BMA. However, this decrease is different with various drugs due to the interaction of the drug with the gel. Differences by a factor of two were found in our set of drugs. Therefore, each new drug should be tested in this way. In addition a routine testing of dialysing devices by an NaCl solution is suggested as a method for detecting technological imperfections and calibrating the deviations from standard parameters. A chemical modification of the membrane is recommended as the best way for controlling the permeation rate.
测量了四种抗肿瘤药物在由亲水性甲基丙烯酸酯凝胶制备的膜上的渗透参数，并与氯化钠的渗透情况进行了比较。结果发现，通过增加甲基丙烯酸丁酯（BMA）与甲基丙烯酸羟乙酯（HEMA）的比例，在BMA含量为20%时，扩散速率可降低至几乎为零。然而，由于药物与凝胶的相互作用，不同药物的这种降低情况有所不同。在我们所研究的一组药物中发现了两倍的差异。因此，每种新药都应以这种方式进行测试。此外，建议用氯化钠溶液对透析装置进行常规测试，作为检测技术缺陷和校准与标准参数偏差的一种方法。建议对膜进行化学改性，作为控制渗透速率的最佳方法。
