Zentner G M, Cardinal J R, Kim S W
J Pharm Sci. 1978 Oct;67(10):1347-51. doi: 10.1002/jps.2600671003.
The potential of several commercially available polymeric materials for use in controlled-release drug delivery devices was investigated. Progesterone was used as a model hydrophobic drug. The progesterone permeation rates through polydimethylsiloxane, two polyether urethanes, a hydroxyethyl methacrylate, a polyether urethan--polydimethylsiloxane blend, and a cellulosic membrane were determined. The permeabilities were obtained on nonsoaked membranes and on membranes soaked in plasma for varying times. The purpose of the plasma soaks was to examine the effects of lipid absorption and degradative processes within the membrane on progesterone permeability. This study identified several polymers that show potential for use in controlled-release drug delivery devices. The plasma treatment studies showed that several polymers may not be acceptable. The plasma soak studies were interpreted in terms of the mechanisms of drug permeation through the membranes.
研究了几种市售聚合材料在控释给药装置中的应用潜力。孕酮被用作模型疏水性药物。测定了孕酮通过聚二甲基硅氧烷、两种聚醚聚氨酯、甲基丙烯酸羟乙酯、聚醚聚氨酯 - 聚二甲基硅氧烷共混物和纤维素膜的渗透速率。在未浸泡的膜以及在血浆中浸泡不同时间的膜上获得渗透率。血浆浸泡的目的是研究膜内脂质吸收和降解过程对孕酮渗透性的影响。本研究确定了几种显示出在控释给药装置中应用潜力的聚合物。血浆处理研究表明，几种聚合物可能不可接受。根据药物透过膜的机制对血浆浸泡研究进行了解释。
