Zentner G M, Cardinal J R, Kim S W
J Pharm Sci. 1978 Oct;67(10):1352-5. doi: 10.1002/jps.2600671004.
The potential use of hydrogels in controlled-release drug delivery systems for contraceptive steroids was investigated. The permeabilities, diffusion coefficients, and partition coefficients for progesterone were determined for hydrogels made from hydroxyethyl methacrylate containing varying amounts of ethylene glycol dimethacrylate and tetraethylene glycol dimethacrylate. In addition, copolymers of hydroxyethyl methacrylate with methoxyethyl methacrylate and methoxyethoxyethyl methacrylate were investigated. The results were interpreted in terms of the mechanisms of permeation of progesterone through the hydrogels. This study showed that progesterone permeated these membranes primarily through loose pores in the hydrogel network except at high concentrations of the cross-linker, ethylene glycol dimethacrylate, where dissolution and diffusion of the progesterone in the polymer network was the dominant mechanism.
研究了水凝胶在甾体避孕药控释给药系统中的潜在应用。测定了由含有不同量乙二醇二甲基丙烯酸酯和四甘醇二甲基丙烯酸酯的甲基丙烯酸羟乙酯制成的水凝胶对孕酮的渗透率、扩散系数和分配系数。此外，还研究了甲基丙烯酸羟乙酯与甲氧基乙基甲基丙烯酸酯和甲氧基乙氧基乙基甲基丙烯酸酯的共聚物。根据孕酮透过水凝胶的渗透机制对结果进行了解释。这项研究表明，孕酮主要通过水凝胶网络中的疏松孔渗透这些膜，但在高浓度交联剂乙二醇二甲基丙烯酸酯存在的情况下，孕酮在聚合物网络中的溶解和扩散是主要机制。
