噬菌体phi W-14感染的食酸假单胞菌中α-腐胺基胸腺嘧啶生物合成的研究
Studies on the biosynthesis of alpha-putrescinylthymine in bacteriophage phi W-14-infected Pseudomonas acidovorans.
作者信息
Kelln R A, Warren R A
出版信息
J Virol. 1973 Dec;12(6):1427-33. doi: 10.1128/JVI.12.6.1427-1433.1973.
Abstract
The alpha-putrescinylthymine (putThy) in bacteriophage phiW-14 DNA is synthesized at the mononucleotide level: it is labeled by uracil or deoxyuridine but not by thymidine, and it appears in the acid-soluble pool of infected cells before the onset of phage DNA synthesis. The methylene group at the C-5 position of the pyrimidine moiety of putThy is derived in vivo from a C(1) unit. Extracts of a phage infected thymidine auxotroph of the host, Pseudomonas acidovorans, apparently contain a phage-specific thymidylate synthetase and a phage-specific activity which forms 5-hydroxymethyl dUMP from N(5), N(10)-methylene-tetrahydrofolate and dUMP.
摘要
噬菌体phiW - 14 DNA中的α-腐胺基胸腺嘧啶（putThy）是在单核苷酸水平合成的：它可被尿嘧啶或脱氧尿苷标记，但不能被胸腺嘧啶标记，并且在噬菌体DNA合成开始之前就出现在受感染细胞的酸溶性池中。putThy嘧啶部分C - 5位的亚甲基在体内源自一个C(1)单位。宿主食酸假单胞菌的噬菌体感染胸苷营养缺陷型提取物显然含有一种噬菌体特异性胸苷酸合成酶和一种噬菌体特异性活性，该活性可由N(5)，N(10)-亚甲基四氢叶酸和dUMP形成5-羟甲基dUMP。
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