皮肤感觉神经元特异性的获得：对体被特异性假说的重新思考。

Proc Natl Acad Sci U S A. 1973 Dec;70(12):3684-8. doi: 10.1073/pnas.70.12.3684.

Neuronal specificity in cutaneous sensory nerve cells has been postulated to arise from "inductive interactions" between the cell's randomly outgrown peripheral neurite and local biochemical markers in the skin. Here was apply this integumental specification hypothesis to data recently obtained on the wiping-reflex behavior of frogs skin-grafted at various times during larval life. Deductions are generated about the developmental time course of the postulated nerve-skin interactions and two predictions are formulated and tested. Because the results of serial skin rotation experiments contradict the predictions, we conclude that the currently held hypothesis must be seriously questioned.

皮肤感觉神经细胞的神经元特异性被假定源于细胞随机长出的外周神经突与皮肤中局部生化标记之间的“诱导相互作用”。在此，我们将这一皮肤特异性假说应用于最近获得的关于在幼虫生活的不同时期进行皮肤移植的青蛙的擦拭反射行为的数据。由此推断出假定的神经 - 皮肤相互作用的发育时间进程，并提出并检验了两个预测。由于连续皮肤旋转实验的结果与预测相矛盾，我们得出结论，目前所秉持的假说必须受到严重质疑。