大肠杆菌K12中不同的操纵子与麦芽糖B区域的遗传结构
Divergent operons and the genetic structure of the maltose B region in Escherichia coli K12.
作者信息
Hofnung M
出版信息
Genetics. 1974 Feb;76(2):169-84. doi: 10.1093/genetics/76.2.169.
Abstract
Complementation and polarity suppression data are interpreted in terms of the genetic structure of the maltose B region. It is proposed that this region comprises two divergent operons. One operon includes malK, a cistron involved in maltose permeation, and lamB the only known cistron specifically involved in lambda receptor synthesis. The other operon includes malJ(1) and malJ(2) which are most probably two different cistrons, both involved in maltose permeation*. It is further assumed that expression of the two operons is controlled by malT, the positive regulatory gene of the maltose system, located in the malA region. The target(s) for the action of the malT product is (are) most likely to be located between malJ(1) and malK. There is an indication that the two operons might overlap in the region of their promoters. The structure of such an overlap as well as the possible function of the products of the different cistrons in malB are briefly discussed.
摘要
互补和极性抑制数据根据麦芽糖B区域的遗传结构进行解释。有人提出，该区域由两个不同的操纵子组成。一个操纵子包括malK，一个参与麦芽糖通透的顺反子，以及lamB，唯一已知的专门参与λ受体合成的顺反子。另一个操纵子包括malJ(1)和malJ(2)，它们很可能是两个不同的顺反子，都参与麦芽糖通透*。进一步假设这两个操纵子的表达受位于malA区域的麦芽糖系统的正调控基因malT控制。malT产物作用的靶标最有可能位于malJ(1)和malK之间。有迹象表明这两个操纵子在其启动子区域可能重叠。简要讨论了这种重叠的结构以及malB中不同顺反子产物的可能功能。
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Amber suA mutations which relieve polarity.缓解极性的琥珀酸琥珀突变。
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