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血管性脑桥中脑病变后昏迷状态持续八年。

Comatose state maintained during eight years following a vascular ponto-mesencephalic lesion.

作者信息

Obrador S, Reinoso-Suarez F, Carbonell J, Martinez-Moreno E, Navarro H, Oliva H, Oliveros J C, Cordoba A

出版信息

Electroencephalogr Clin Neurophysiol. 1975 Jan;38(1):21-6. doi: 10.1016/0013-4694(75)90206-0.

DOI:10.1016/0013-4694(75)90206-0
PMID:45900
Abstract

A 24-year-old man survived for 8 years after a vascular lesion of the pons and midbrain. During these years a subresponsive comatose state with neurological signs extending from the oculomotor nuclei to the trigeminal and facial nuclei levels was present. A decorticated type of rigidity, with bilateral paralysis of the limbs accompanied by pyramidal signs, was also present. The EEG during the first months showed slow activity which afterwards gradually changed towards fast and alpha activities, maintained in the course of the years. The pathological diagnosis was a fibrous endarteritis, mainly in the territory of the basilar and vertebral arteries. The pons and midbrain, presenting a large cystic infarct, were serially studied to determine the anatomical extent of the lesion. After reviewing other examples from the literature, the clinical features of our case are discussed. The evolution of the EEG is related to different structures of the ponto-mesencephalic region with different functional activities.

摘要

一名24岁男性在脑桥和中脑发生血管病变后存活了8年。在这些年里,他处于一种反应迟钝的昏迷状态,伴有从动眼神经核延伸至三叉神经和面神经核水平的神经体征。还存在一种去皮质强直类型,伴有四肢双侧瘫痪及锥体束征。最初几个月的脑电图显示为慢波活动,之后逐渐转变为快波和α波活动,并在数年中持续存在。病理诊断为纤维性动脉内膜炎,主要累及基底动脉和椎动脉区域。对呈现大面积囊性梗死的脑桥和中脑进行了系列研究,以确定病变的解剖范围。在回顾了文献中的其他病例后,对我们病例的临床特征进行了讨论。脑电图的演变与脑桥-中脑区域具有不同功能活动的不同结构有关。

相似文献

1
Comatose state maintained during eight years following a vascular ponto-mesencephalic lesion.血管性脑桥中脑病变后昏迷状态持续八年。
Electroencephalogr Clin Neurophysiol. 1975 Jan;38(1):21-6. doi: 10.1016/0013-4694(75)90206-0.
2
"Locked-in" state with bilateral midbrain infarcts.
Arch Neurol. 1974 Feb;30(2):176-8. doi: 10.1001/archneur.1974.00490320064009.
3
Brainstem lesion with coma for five years following manipulation of the cervical spine.
J Neurol. 1978 May 18;218(2):97-105.
4
[Clinical and pathologic-anatomic findings in acute basilar thromboses. A study of 30 autopsy verified cases].
Nervenarzt. 1990 Feb;61(2):83-7.
5
Multiple cerebral arterial thromboses on a background of vascular hypoplasia.血管发育不全背景下的多发性脑动脉血栓形成。
Schweiz Arch Neurol Neurochir Psychiatr. 1974;114(2):205-13.
6
Thrombosis of the mesencephalic artery. A clinico-pathological study of two cases and its correlation with the arterial vascularisation.中脑动脉血栓形成。两例临床病理研究及其与动脉血管形成的相关性。
Acta Neurol Belg. 1977 May-Jun;77(3):151-62.
7
Phycomycotic thrombosis of the basilar artery.
Neurology. 1968 Aug;18(8):807-12. doi: 10.1212/wnl.18.8.807.
8
Bilateral occlusion of basilar artery branches.双侧基底动脉分支闭塞。
J Neurol Neurosurg Psychiatry. 1977 Dec;40(12):1182-9. doi: 10.1136/jnnp.40.12.1182.
9
Pontine hemorrhagic infarction in nontraumatic fat embolism.非创伤性脂肪栓塞中的脑桥出血性梗死
Neurology. 1988 Oct;38(10):1645-7. doi: 10.1212/wnl.38.10.1645.
10
Syndrome of the mesencephalic artery: report of a case with CT and necropsy findings.中脑动脉综合征:一例CT及尸检结果报告。
J Neurol Neurosurg Psychiatry. 1985 Nov;48(11):1179-81. doi: 10.1136/jnnp.48.11.1179.

引用本文的文献

1
Heralding manifestations of basilar artery occlusion with lethal or severe stroke.基底动脉闭塞伴致死性或严重卒中的先兆表现。
J Neurol Neurosurg Psychiatry. 2003 Dec;74(12):1621-6. doi: 10.1136/jnnp.74.12.1621.
2
Classification of coma.昏迷的分类。
Acta Neurochir (Wien). 1976;34(1-4):5-10. doi: 10.1007/BF01405858.
3
Brainstem lesion with coma for five years following manipulation of the cervical spine.
J Neurol. 1978 May 18;218(2):97-105.
4
Bilateral symmetrical softening of the thalamus.丘脑双侧对称性软化。
J Neurol. 1977 Dec 1;217(1):57-65. doi: 10.1007/BF00316317.