噬菌体T7基因3（T7核酸内切酶I）中的一个突变被噬菌体和宿主多核苷酸连接酶中的突变所抑制。
Suppression of a mutation in gene 3 of bacteriophage T7 (T7 endonuclease I) by mutations in phage and host polynucleotide ligase.
作者信息
Sadowski P D
出版信息
J Virol. 1974 Jan;13(1):226-9. doi: 10.1128/JVI.13.1.226-229.1974.
Abstract
Bacteriophage T7 bearing amber mutations in both gene 1.3 (T7 DNA ligase) and gene 3 (T7 endonuclease I) are viable when grown in suppressor-negative, ligase-negative hosts. This is evidenced by a high plating efficiency and a large burst size compared to the single mutants. These findings may be explained by a limited destruction of cellular DNA by the double mutant.
摘要
在基因1.3（T7 DNA连接酶）和基因3（T7核酸内切酶I）中均带有琥珀突变的噬菌体T7，在抑制因子阴性、连接酶阴性的宿主中生长时是可行的。与单突变体相比，高平板效率和大的爆发量证明了这一点。这些发现可能是由于双突变体对细胞DNA的破坏有限所致。
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