Yamada E, Hazama F, Amano S, Hanakita J
Jpn Circ J. 1979 Apr;43(4):285-92. doi: 10.1253/jcj.43.285.
Changes in acid phosphatase activity in the cerebrovascular system and brain parenchyma in SHR were investigated histochemically. An increased activity of the enzyme was demonstrated in the SHR endothelial and medial smooth muscle cells of the cerebral arterial system as compared to the control. The pericytes of intraparenchymal blood vessels also showed an intensified enzyme activity. The enzyme activity increased with advancing age. In SHR brain parenchyma, the enzyme activity was decreased in the cortical nerve cells. Glial cells with the enzyme activity were increased in number and showed an intensified activity. Causative factors of changes in acid phosphatase activity in SHR cerebral arteries and parenchyma were discussed.
采用组织化学方法研究了自发性高血压大鼠（SHR）脑血管系统和脑实质中酸性磷酸酶活性的变化。与对照组相比，SHR脑动脉系统的内皮细胞和中膜平滑肌细胞中该酶的活性增加。脑实质内血管的周细胞也显示出酶活性增强。酶活性随年龄增长而增加。在SHR脑实质中，皮质神经细胞中的酶活性降低。具有酶活性的神经胶质细胞数量增加且活性增强。讨论了SHR脑动脉和脑实质中酸性磷酸酶活性变化的致病因素。
