Amano S, Matsumoto M, Hazama F, Yamada E, Ohkawa K
Jpn Circ J. 1981 Nov;45(11):1264-71. doi: 10.1253/jcj.45.1264.
5'-Nucleotidase activity in the cerebrovascular system in stroke-prone spontaneously hypertensive rats was histochemically investigated. In the hypertensive rats, an enhancement of 5'-nucleotidase activity was observed already in the early stage of hypertension and the enzyme activity increased with advancing age. The enzyme activity appeared earlier and stronger in the larger arteries in the basal portion than the pial arteries in the convexity of the brain and arterioles in the brain parenchyma. The activity in the arterial walls proved to be particularly strong in the thickened parts showing cellular hyperplasia, mainly at the branching portions. The reaction products localized along the plasma membrane, and also in the cytoplasma in some parts where the activity was strong. Relationship between the increased 5'-nucleotidase activity and aging of the cells composing the cerebrovasculature resulted from an accelerated or repeated cell proliferation was discussed.
采用组织化学方法研究了易卒中型自发性高血压大鼠脑血管系统中的5'-核苷酸酶活性。在高血压大鼠中，在高血压早期就观察到5'-核苷酸酶活性增强，且酶活性随年龄增长而增加。该酶活性在脑底部较大动脉中比脑凸面软脑膜动脉和脑实质小动脉出现得更早且更强。动脉壁中的活性在显示细胞增生的增厚部分，主要是在分支部位，表现得尤为强烈。反应产物定位于质膜沿线，在某些活性较强的部位也存在于细胞质中。讨论了5'-核苷酸酶活性增加与构成脑血管系统的细胞衰老之间的关系，这种关系是由加速或反复的细胞增殖导致的。
