Kikuchi N, Kobayashi A, Kanno H, Ishihara K, Kato S, Kiuchi N, Iwama S, Mori Y
Jpn J Antibiot. 1979 Apr;32(4):555-61.
The clinical efficacy of a macrolide antibiotic, midecamycin, was studied in 12 adult cases with Mycoplasma pneumoniae pneumonia. The therapeutic effects were excellent or good in 9 cases and fair in 2 cases. On defervescence and disappearance of shadows on chest X-ray the therapeutic effect was satisfactory, but on disappearance of cough therapeutic effect was not clear in some cases. Taking into consideration the antimicrobial activity of midecamycin against Mycoplasma pneumoniae, serum concentration and side effects of midecamycin, this antibiotic is expected to be effective in the treatment of Mycoplasma pneumoniae pneumonia.
对12例成人肺炎支原体肺炎患者研究了大环内酯类抗生素麦迪霉素的临床疗效。9例治疗效果为优或良,2例为中。在退热和胸部X线阴影消失方面治疗效果令人满意,但在咳嗽消失方面,部分病例治疗效果不明确。考虑到麦迪霉素对肺炎支原体的抗菌活性、血清浓度及副作用,预计该抗生素对肺炎支原体肺炎治疗有效。