交沙霉素与红霉素治疗肺炎支原体肺炎的比较。
Comparison of josamycin and erythromycin in the therapy of Mycoplasma pneumoniae pneumonia.
作者信息
Wenzel R P, Hendley J O, Dodd W K, Gwaltney J M
出版信息
Antimicrob Agents Chemother. 1976 Dec;10(6):899-901. doi: 10.1128/AAC.10.6.899.
A controlled, double-blind study was performed to compare the efficacy of two macrolide antibiotics, erythromycin and josamycin, in the therapy of Mycoplasma pneumoniae pneumonia. Marine Corps recruit volunteers received one of the two antibiotics in a dosage of 2 g daily for 7 days. Twelve of 21 men treated with josamycin and 9 of 25 men treated with erythromycin had confirmed M. pneumoniae pneumonia. The josamycin-treated group remained hospitalized for 5.4 +/- 1.2 days compared to 5.1 +/- 2.0 days for the erythromycin-treated group (0.60 > P > 0.50). Fever days were similar for the josamycin-treated (1.4 +/- 0.4) and erythromycin-treated (1.2 +/- 0.3) groups (P = 0.95). There was no difference in resolution of signs and symptoms of illness in the two study populations. Thus, josamycin is as efficacious as erythromycin in the therapy of M. pneumoniae pneumonia.
进行了一项对照双盲研究，以比较两种大环内酯类抗生素（红霉素和交沙霉素）治疗肺炎支原体肺炎的疗效。海军陆战队招募的志愿者接受两种抗生素中的一种，剂量为每日2克，共7天。接受交沙霉素治疗的21名男性中有12人、接受红霉素治疗的25名男性中有9人确诊为肺炎支原体肺炎。交沙霉素治疗组的住院时间为5.4±1.2天，而红霉素治疗组为5.1±2.0天（0.60＞P＞0.50）。交沙霉素治疗组（1.4±0.4）和红霉素治疗组（1.2±0.3）的发热天数相似（P = 0.95）。两个研究人群中疾病体征和症状的缓解情况没有差异。因此，交沙霉素在治疗肺炎支原体肺炎方面与红霉素疗效相当。
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