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慢性肝病患者肝活检中前胶原脯氨酰羟化酶和N-乙酰-β-葡萄糖苷酶的活性

Activity of procollagen-prolyl-hydroxylase and N-acetyl-beta-glucosaminidase in liver biopsies from patients with chronic liver diseases.

作者信息

Pott G, Eberhardt G, Gerlach U

出版信息

Klin Wochenschr. 1979 Jun 1;57(11):587-8. doi: 10.1007/BF01491138.

DOI:10.1007/BF01491138
PMID:459373
Abstract

In 5 mg of liver tissue obtained by needle biopsy from patients with chronic liver diseases, activity of both Procollagen-prolyl-hydroxylase and N-Acetyl-beta-glucosaminidase was measured. The activity of both enzymes increased due to the activity of fibrosis, but prolylhydroxylase increased more. The relation of these two enzyme activities in the development of liver fibrosis is discussed.

摘要

在通过针吸活检从慢性肝病患者获取的5毫克肝脏组织中，测定了前胶原脯氨酰羟化酶和N-乙酰-β-葡萄糖苷酶的活性。由于纤维化活动，两种酶的活性均增加，但脯氨酰羟化酶增加得更多。讨论了这两种酶活性在肝纤维化发展中的关系。

相似文献

1
Activity of procollagen-prolyl-hydroxylase and N-acetyl-beta-glucosaminidase in liver biopsies from patients with chronic liver diseases.慢性肝病患者肝活检中前胶原脯氨酰羟化酶和N-乙酰-β-葡萄糖苷酶的活性
Klin Wochenschr. 1979 Jun 1;57(11):587-8. doi: 10.1007/BF01491138.
2
Activity of isoenzyme A and N-acetyl-beta-glucosaminidase in fibrotic liver tissue.纤维化肝组织中同工酶A和N-乙酰-β-氨基葡萄糖苷酶的活性。
Hepatogastroenterology. 1980 Dec;27(6):465-7.
3
[Correlation between the mesenchyma reaction in fibrosing liver diseases and N-acetyl-beta-glucosaminidase (beta-NAG) activity].[纤维化肝病中间充质反应与N-乙酰-β-葡萄糖苷酶（β-NAG）活性之间的相关性]
Verh Dtsch Ges Pathol. 1978;62:396.
4
Connective tissue components of the normal and fibrotic human liver. II. Clinical aspects.正常及纤维化人类肝脏的结缔组织成分。II. 临床方面。
Klin Wochenschr. 1982 Jan 4;60(1):1-7. doi: 10.1007/BF01721581.
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[Clinical value of N-acetyl-beta-D-glucosaminidase and alpha-galactosidase in liver diseases].N-乙酰-β-D-氨基葡萄糖苷酶和α-半乳糖苷酶在肝脏疾病中的临床价值
Z Gesamte Inn Med. 1981 Jul 1;36(13):457-9.
6
Acid hydrolase activities and lysosomal integrity in liver biopsies from patients with iron overload.铁过载患者肝脏活检中的酸性水解酶活性和溶酶体完整性。
Clin Sci Mol Med. 1976 Jan;50(1):75-8. doi: 10.1042/cs0500075.
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Enzyme activities of collagen peptidase (CP), monoaminoxidase (MAO) and N-acetyl-beta-D-glucosaminidase (beta-NAG) as fibrosis marker in chronic liver diseases.胶原肽酶（CP）、单胺氧化酶（MAO）和N-乙酰-β-D-氨基葡萄糖苷酶（β-NAG）的酶活性作为慢性肝病纤维化标志物的研究
Dtsch Z Verdau Stoffwechselkr. 1988;48(1):27-34.
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Serum concentration of procollagen-III-peptide in comparison with the serum activity of N-acetyl-beta-glucosaminidase for diagnosis of the activity of liver fibrosis in patients with chronic active liver diseases.慢性活动性肝病患者血清中Ⅲ型前胶原肽浓度与N-乙酰-β-氨基葡萄糖苷酶血清活性在肝纤维化活动诊断中的比较。
Clin Chim Acta. 1981 May;112(3):365-9. doi: 10.1016/0009-8981(81)90461-7.
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The diagnostic potential of the combined determination of serum monoamine oxidase and N-acetyl-beta-D-glucosaminidase for fibroproliferative liver diseases.血清单胺氧化酶和N-乙酰-β-D-氨基葡萄糖苷酶联合检测对纤维增生性肝病的诊断潜力
J Clin Chem Clin Biochem. 1983 Jan;21(1):19-23. doi: 10.1515/cclm.1983.21.1.19.
10
Isoenzymes of N-acetyl-beta-glucosaminidase from human liver and serum: separation by electrofocusing in thin layers of polyacrylamide gel.来自人肝脏和血清的N-乙酰-β-氨基葡萄糖苷酶同工酶：在聚丙烯酰胺凝胶薄层中通过电聚焦进行分离。
J Clin Chem Clin Biochem. 1978 Jan;16(1):15-8. doi: 10.1515/cclm.1978.16.1.15.

引用本文的文献

1
Connective tissue components of the normal and fibrotic human liver. II. Clinical aspects.正常及纤维化人类肝脏的结缔组织成分。II. 临床方面。
Klin Wochenschr. 1982 Jan 4;60(1):1-7. doi: 10.1007/BF01721581.

本文引用的文献

1
Inhibition of glycosidases by aldonolactones of corresponding configuration. 2. Inhibitors of beta-N-acetylglucosaminidase.相应构型的醛糖内酯对糖苷酶的抑制作用。2. β-N-乙酰氨基葡萄糖苷酶的抑制剂。
Biochem J. 1958 Jul;69(3):467-76. doi: 10.1042/bj0690467.
2
[A colorimetric routine methods for determination of small quantities of proteins in body fluids and tissues].[一种用于测定体液和组织中少量蛋白质的比色常规方法]
Klin Wochenschr. 1953 Sep 1;31(33-34):798-802. doi: 10.1007/BF01472663.
3
Protocollagen proline hydroxylase in normal liver and in hepatic fibrosis.
正常肝脏和肝纤维化中的原胶原脯氨酸羟化酶
Gastroenterology. 1969 Apr;56(4):744-50.
4
Activities of prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase in the liver of rats with hepatic injury.肝损伤大鼠肝脏中脯氨酰羟化酶、赖氨酰羟化酶、胶原半乳糖基转移酶和胶原葡萄糖基转移酶的活性。
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Prolyl hydroxylase.脯氨酰羟化酶
Adv Enzymol Relat Areas Mol Biol. 1974;41(0):245-300. doi: 10.1002/9780470122860.ch6.
6
Collagen proline hydroxylase activity and 35S sulphate uptake in human liver biopsies.人肝活检组织中胶原蛋白脯氨酸羟化酶活性及35S硫酸盐摄取情况
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Serum hyaluronidase activity in chronic liver damage.慢性肝损伤中的血清透明质酸酶活性
Clin Chim Acta. 1970 Jan;27(1):47-52. doi: 10.1016/0009-8981(70)90372-4.
8
Increased protocollagen hydroxylase activity in the livers of rats with hepatic fibrosis.肝纤维化大鼠肝脏中原胶原蛋白羟化酶活性增加。
Biochem Biophys Res Commun. 1967 Sep 27;28(6):940-4. doi: 10.1016/0006-291x(67)90070-8.
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N-acetyl-beta-hexosaminidase: role in the degradation of glycosaminoglycans.N-乙酰-β-己糖胺酶：在糖胺聚糖降解中的作用。
Science. 1973 Aug 31;181(4102):866-7. doi: 10.1126/science.181.4102.866.
10
The biosynthesis of collagen. 1.胶原蛋白的生物合成。1.
N Engl J Med. 1972 Jan 27;286(4):194-9. doi: 10.1056/NEJM197201272860406.