Brown H R, Thormar H
Acta Neuropathol. 1976 Nov 15;36(3):259-67. doi: 10.1007/BF00685370.
Nuclear bodies have been found with great consistency in brain tissue from patients with subacute sclerosing panencephalitis (SSPE). There has been controversy as to the significance of these structures and their relationship, if any, to the disease. In this study, a non-productive, cell-associated strain of SSPE measles virus grown in tissue culture on Vero cells showed the continued presence of nuclear bodies, frequently in close association with the continued presence of nuclear bodies, frequently in close association with the SSPE measles virus nucleocapsids. Immunoperoxidase (I-P) staining with specific antiserum against measles virus nucleocapsids was done. The resultant positive labeling of the nuclear bodies demonstrates that they contain measles virus antigen and suggests that the nuclear bodies play a role in the development of the measles virus nucleocapsids of SSPE.
在亚急性硬化性全脑炎（SSPE）患者的脑组织中，核体一直被高度一致地发现。关于这些结构的意义以及它们与疾病的关系（如果有的话）一直存在争议。在本研究中，在Vero细胞上的组织培养中生长的一株非增殖性、细胞相关的SSPE麻疹病毒显示核体持续存在，常常与SSPE麻疹病毒核衣壳的持续存在密切相关。用针对麻疹病毒核衣壳的特异性抗血清进行免疫过氧化物酶（I-P）染色。核体的阳性标记结果表明它们含有麻疹病毒抗原，并提示核体在SSPE麻疹病毒核衣壳的形成中起作用。
