Smith M G, Williams R, Walker G, Rizzetto M, Doniach D
Br Med J. 1974 Apr 13;2(5910):80-4. doi: 10.1136/bmj.2.5910.80.
A study of the clinical associations of a recently defined tissue autoantibody, the liver/kidney microsomal (L.K.M.) antibody, showed that out of 33 patients 26 had clinical liver disease. Fifteen of the patients had active chronic hepatitis and there were seven cases of acute hepatitis, precipitated by presumed virus A infection in three instances and by drug hypersensitivity in the other four. The remaining cases with liver disease included two with subclinical hepatitis and two with hepatocellular carcinoma. Evidence is presented that the patients with active chronic hepatitis may represent a distinct subgroup of the disease with a young mean age, an even male to female ratio, and a striking lack of other nonorgan-specific autoantibodies-that is, antinuclear and smooth muscle-which are usually present in the other autoimmune variant of the disease.
一项针对最近定义的组织自身抗体——肝/肾微粒体（L.K.M.）抗体的临床关联研究表明，在33例患者中，26例患有临床肝病。其中15例为活动性慢性肝炎，7例为急性肝炎，3例急性肝炎由推测的甲型病毒感染诱发，另外4例由药物过敏引起。其余肝病病例包括2例亚临床肝炎和2例肝细胞癌。有证据表明，活动性慢性肝炎患者可能代表该疾病的一个独特亚组，其平均年龄较轻，男女比例均衡，且明显缺乏其他非器官特异性自身抗体，即抗核抗体和平滑肌抗体，而这些抗体通常存在于该疾病的其他自身免疫变体中。
