耐磺胺嘧啶银阴沟肠杆菌的特性。
Properties of silver sulfadiazine-resistant Enterobacter cloacae.
作者信息
Rosenkranz H S, Coward J E, Wlodkowski T J, Carr H S
出版信息
Antimicrob Agents Chemother. 1974 Feb;5(2):199-201. doi: 10.1128/AAC.5.2.199.
Abstract
Two silver sulfadiazine-resistant isolates of Enterobacter cloacae obtained in a burns unit where the drug was in use were studied. These strains were resistant to elevated levels of the drug, and they were cross-resistant to silver benzoate, but not to silver nitrate. Growth of the strains in nutritionally poor defined media sensitized them to the inhibitory action of the drug. Exposure of the bacteria to penicillins rendered them susceptible to silver sulfadiazine. The resistant bacteria harbored episomes for resistance to carbenicillin and kanamycin; however, resistance to silver sulfadiazine could not be transferred by these episomes. Twenty-three strains of E. cloacae isolated in a general hospital were sensitive to much lower levels of the drug (</=50 mug/ml).
摘要
对在一个使用该药物的烧伤病房分离出的两株耐磺胺嘧啶银的阴沟肠杆菌进行了研究。这些菌株对较高浓度的该药物具有抗性，并且对苯甲酸银交叉耐药，但对硝酸银不耐药。这些菌株在营养贫乏的限定培养基中生长使其对该药物的抑制作用敏感。将这些细菌暴露于青霉素使其对磺胺嘧啶银敏感。耐药菌携带对羧苄青霉素和卡那霉素耐药的附加体；然而，这些附加体不能转移对磺胺嘧啶银的耐药性。在一家综合医院分离出的23株阴沟肠杆菌对低得多的药物浓度（≤50μg/ml）敏感。
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