噬菌体φX174的基因A起始子的分离及其功能，一种高度特异性的DNA内切酶
Isolation and function of the gene A initiator of bacteriophage phi-chi 174, a highly specific DNA endonuclease.
作者信息
Henry T J, Knippers R
出版信息
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1549-53. doi: 10.1073/pnas.71.4.1549.
Abstract
The gene A product of Escherichia coli bacteriophage varphiX 174, necessary for initiation of varphiX DNA synthesis, has been identified and purified to near homogeneity. The gene A protein is shown to be a highly specific DNA endonuclease which breaks one phosphodiester bond in the viral strand of either double-stranded, circular varphiX replicative form I (RFI), or in single-stranded, circular varphiX viral DNA; it is inactive against all other species of DNA tested.
摘要
大肠杆菌噬菌体φX 174的基因A产物是启动φX DNA合成所必需的，现已被鉴定并纯化至近乎均一。基因A蛋白被证明是一种高度特异性的DNA内切酶，它能在双链环状φX复制型I（RFI）的病毒链或单链环状φX病毒DNA中切断一个磷酸二酯键；对所有其他测试的DNA种类均无活性。
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本文引用的文献
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