酵母中酪氨酸抑制型DAHP合成酶基因的反馈不敏感突变体。
Feedback-insensitive mutants of the gene for the tyrosine-inhibited DAHP synthetase in yeast.
作者信息
Meuris P
出版信息
Genetics. 1974 Apr;76(4):735-44. doi: 10.1093/genetics/76.4.735.
Abstract
A yeast strain lacking the phenylalanine-sensitive DAHP synthetase exhibits a tyrosine-inhibited phenotype. Reversions from this phenotype were selected. They were the result of mutations affecting the tyrosine-sensitive DAHP synthetase which became insensitive to feedback inhibition, as shown by genetic and enzymatic studies. The feedback-insensitive mutations were located at five different sites scattered on the map of the aro4 gene.
摘要
一种缺乏苯丙氨酸敏感型DAHP合成酶的酵母菌株表现出酪氨酸抑制型表型。我们筛选了从这种表型回复突变的菌株。遗传和酶学研究表明，这些回复突变是由影响酪氨酸敏感型DAHP合成酶的突变引起的，该酶变得对反馈抑制不敏感。反馈不敏感突变位于aro4基因图谱上分散的五个不同位点。
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