酵母中酪氨酸抑制型DAHP合成酶基因的反馈不敏感突变体。
Feedback-insensitive mutants of the gene for the tyrosine-inhibited DAHP synthetase in yeast.
作者信息
Meuris P
出版信息
Genetics. 1974 Apr;76(4):735-44. doi: 10.1093/genetics/76.4.735.
Abstract
A yeast strain lacking the phenylalanine-sensitive DAHP synthetase exhibits a tyrosine-inhibited phenotype. Reversions from this phenotype were selected. They were the result of mutations affecting the tyrosine-sensitive DAHP synthetase which became insensitive to feedback inhibition, as shown by genetic and enzymatic studies. The feedback-insensitive mutations were located at five different sites scattered on the map of the aro4 gene.
摘要
一种缺乏苯丙氨酸敏感型DAHP合成酶的酵母菌株表现出酪氨酸抑制型表型。我们筛选了从这种表型回复突变的菌株。遗传和酶学研究表明，这些回复突变是由影响酪氨酸敏感型DAHP合成酶的突变引起的，该酶变得对反馈抑制不敏感。反馈不敏感突变位于aro4基因图谱上分散的五个不同位点。
相似文献
1
Feedback-insensitive mutants of the gene for the tyrosine-inhibited DAHP synthetase in yeast.
Genetics. 1974 Apr;76(4):735-44. doi: 10.1093/genetics/76.4.735.
2
Isolation of DAHP synthetase by tyrosine-affinity chromatography.
Methods Enzymol. 1974;34:394-8. doi: 10.1016/s0076-6879(74)34044-x.
3
Repression of aromatic amino acid biosynthesis in Escherichia coli K-12.
J Bacteriol. 1971 Oct;108(1):386-99. doi: 10.1128/jb.108.1.386-399.1971.
4
Phenylalanine and tyrosine biosynthesis in Escherichia coli K-12: mutants derepressed for 3-deoxy-D-arabinoheptulosonic acid 7-phosphate synthetase (phe), 3-deoxy-D-arabinoheptulosonic acid 7-phosphate synthetase (tyr), chorismate mutase T-prephenate dehydrogenase, and transaminase A.
J Bacteriol. 1971 Oct;108(1):400-9. doi: 10.1128/jb.108.1.400-409.1971.
5
Anacystis nidulans mutants resistant to aromatic amino acid analogues.
J Bacteriol. 1975 Jun;122(3):943-8. doi: 10.1128/jb.122.3.943-948.1975.
6
Isolation and properties of feedback-insensitive DAHP synthase (phe) mutants of E. coli K 12.
Acta Biochim Biophys Acad Sci Hung. 1973;8(2):81-90.
7
Tyrosine and phenylalanine biosynthesis in Escherichia coli K-12: complementation between different tyrR alleles.
J Bacteriol. 1973 Sep;115(3):1145-50. doi: 10.1128/jb.115.3.1145-1150.1973.
8
Genes and isoenzymes controlling the first step in the aromatic amino acid biosynthesis in Schizosaccharomyces pombe.
Biochim Biophys Acta. 1974 Jun 18;350(2):319-27. doi: 10.1016/0005-2744(74)90506-3.
9
Structural genes for DAHP synthase isoenzymes in Neurospora crassa.
Genetics. 1971 Feb;67(2):183-8. doi: 10.1093/genetics/67.2.183.
10
Feedback regulation of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase from a marine bacterium, Vibrio MB22.
J Bacteriol. 1972 Mar;109(3):1162-9. doi: 10.1128/jb.109.3.1162-1169.1972.
引用本文的文献
1
Comparison of two alternative dominant selectable markers for wine yeast transformation.
Appl Environ Microbiol. 2004 Dec;70(12):7018-23. doi: 10.1128/AEM.70.12.7018-7023.2004.
2
A mutated ARO4 gene for feedback-resistant DAHP synthase which causes both o-fluoro-DL-phenylalanine resistance and beta-phenethyl-alcohol overproduction in Saccharomyces cerevisiae.
Curr Genet. 1991 Dec;20(6):453-6. doi: 10.1007/BF00334771.
3
Regulatory mutants at the his1 locus of yeast.
Genetics. 1979 Jun;92(2):363-82. doi: 10.1093/genetics/92.2.363.
4
Reversion at the HiS1 locus of yeast.
Genetics. 1978 Nov;90(3):489-500. doi: 10.1093/genetics/90.3.489.
本文引用的文献
1
Use of snail digestive juice in isolation of yeast spore tetrads.
J Bacteriol. 1959 Aug;78(2):292. doi: 10.1128/jb.78.2.292-292.1959.
Zotero 插件