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Feedback-insensitive mutants of the gene for the tyrosine-inhibited DAHP synthetase in yeast.酵母中酪氨酸抑制型DAHP合成酶基因的反馈不敏感突变体。
Genetics. 1974 Apr;76(4):735-44. doi: 10.1093/genetics/76.4.735.
2
Isolation of DAHP synthetase by tyrosine-affinity chromatography.通过酪氨酸亲和层析法分离3-脱氧-D-阿拉伯庚酮糖酸-7-磷酸合成酶
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Feedback regulation of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase from a marine bacterium, Vibrio MB22.来自海洋细菌霍乱弧菌MB22的3-脱氧-D-阿拉伯庚酮糖酸-7-磷酸合成酶的反馈调节
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A mutated ARO4 gene for feedback-resistant DAHP synthase which causes both o-fluoro-DL-phenylalanine resistance and beta-phenethyl-alcohol overproduction in Saccharomyces cerevisiae.一种用于反馈抗性DAHP合酶的突变型ARO4基因,其导致酿酒酵母对邻氟-DL-苯丙氨酸产生抗性并过量生产β-苯乙醇。
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Reversion at the HiS1 locus of yeast.酵母中组氨酸1(His1)基因座的回复突变
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本文引用的文献

1
Use of snail digestive juice in isolation of yeast spore tetrads.蜗牛消化液在酵母孢子四分体分离中的应用。
J Bacteriol. 1959 Aug;78(2):292. doi: 10.1128/jb.78.2.292-292.1959.

酵母中酪氨酸抑制型DAHP合成酶基因的反馈不敏感突变体。

Feedback-insensitive mutants of the gene for the tyrosine-inhibited DAHP synthetase in yeast.

作者信息

Meuris P

出版信息

Genetics. 1974 Apr;76(4):735-44. doi: 10.1093/genetics/76.4.735.

DOI:10.1093/genetics/76.4.735
PMID:4599255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213100/
Abstract

A yeast strain lacking the phenylalanine-sensitive DAHP synthetase exhibits a tyrosine-inhibited phenotype. Reversions from this phenotype were selected. They were the result of mutations affecting the tyrosine-sensitive DAHP synthetase which became insensitive to feedback inhibition, as shown by genetic and enzymatic studies. The feedback-insensitive mutations were located at five different sites scattered on the map of the aro4 gene.

摘要

一种缺乏苯丙氨酸敏感型DAHP合成酶的酵母菌株表现出酪氨酸抑制型表型。我们筛选了从这种表型回复突变的菌株。遗传和酶学研究表明,这些回复突变是由影响酪氨酸敏感型DAHP合成酶的突变引起的,该酶变得对反馈抑制不敏感。反馈不敏感突变位于aro4基因图谱上分散的五个不同位点。