氨苄西林和红霉素对星形诺卡菌的协同作用：孵育时间的影响
Synergistic action of ampicillin and erythromycin against Nocardia asteroides: effect of time of incubation.
作者信息
Finland M, Bach M C, Garner C, Gold O
出版信息
Antimicrob Agents Chemother. 1974 Mar;5(3):344-53. doi: 10.1128/AAC.5.3.344.
Abstract
Ampicillin and erythromycin were shown to act synergistically in vitro against the majority of strains of Nocardia asteroides tested. With these strains, the minimal inhibiting concentration (MIC) of each drug when combined was reduced 4- to more than 512-fold as compared with the MIC of each antibiotic acting individually against the same strains. The combined action against other strains was at least additive, and occasionally indifferent, but antagonism was not observed. The duration of incubation greatly influenced the MIC of erythromycin but had less effect on the action of ampicillin. Synergistic action was still demonstrable, although less frequently, when the period of incubation was increased from 48 to 72 h.
摘要
已证明氨苄西林和红霉素在体外对大多数测试的星形诺卡菌菌株具有协同作用。对于这些菌株，与每种抗生素单独作用于相同菌株时的最低抑菌浓度（MIC）相比，联合使用时每种药物的MIC降低了4至超过512倍。对其他菌株的联合作用至少是相加的，偶尔无作用，但未观察到拮抗作用。孵育时间对红霉素的MIC有很大影响，但对氨苄西林的作用影响较小。当孵育时间从48小时增加到72小时时，仍可证明存在协同作用，尽管频率较低。
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