Baltimore R S, Klein J O, Wilcox C, Finland M
Antimicrob Agents Chemother. 1976 Apr;9(4):701-5. doi: 10.1128/AAC.9.4.701.
Thirty-five strains each of Klebsiella and Proteus were tested for susceptibility to mecillinam alone and in combination with ampicillin, carbenicillin, cephalothin, and cefazolin. Antibiotics were considered to be synergistic when there was a >/=fourfold reduction in minimum inhibiting concentration of both antibiotics in the combination as compared with that of each antibiotic alone. Synergy of mecillinam with ampicillin, carbenicillin, cephalothin, and cefazolin was demonstrated against 2, 3, 7, and 8 of the 35 strains of Klebsiella and against 14, 14, 19, and 24 of the 35 strains of Proteus, respectively. Synergy against the isolates of Proteus was related to species, whereas against Klebsiella it was related to susceptibility of the isolates to mecillinam. Tests of combinations of mecillinam with other antibiotics on the same and different species indicated that synergy was related to the antibiotic, the species, and the strains of organisms tested.
对35株克雷伯菌和35株变形杆菌分别进行了美西林单独以及与氨苄西林、羧苄西林、头孢噻吩和头孢唑林联合使用时的药敏试验。当联合使用时两种抗生素的最低抑菌浓度相比各自单独使用时降低≥4倍，则认为这两种抗生素具有协同作用。美西林与氨苄西林、羧苄西林、头孢噻吩和头孢唑林联合使用时，分别对35株克雷伯菌中的2株、3株、7株和8株以及35株变形杆菌中的14株、14株、19株和24株显示出协同作用。对变形杆菌分离株的协同作用与菌种有关，而对克雷伯菌的协同作用则与分离株对美西林的敏感性有关。对同一菌种和不同菌种进行的美西林与其他抗生素联合使用的试验表明，协同作用与所测试的抗生素、菌种以及菌株有关。
