Savageau M A
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2453-5. doi: 10.1073/pnas.71.6.2453.
Whether the regulatory protein of an inducible operon for a catabolic pathway is a positive or a negative element in the control of expression is correlated with the frequent or infrequent presence, respectively, of the system's substrate in the natural environment.
对于分解代谢途径的可诱导操纵子而言,其调节蛋白在表达控制中是正调控元件还是负调控元件,分别与该系统的底物在自然环境中出现的频率高低相关。